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Nature Communications | Genetically-encoded targeted protein degradation technology to remove endogenous condensation-prone proteins and improve crop performance
Author: NRX | Publish date: 2025-01-25 07:43 | Hits: 72
控制基因表达是研究基因功能和遗传改良作物性状的重要手段。随着CRISPR、RNAi和microRNA等技术的发展，研究者已经能够在DNA和mRNA层面对蛋白质编码基因进行靶向调控。然而，针对植物内源…
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Trends Plant Sci | Engineering crop performance with upstream open reading frames
Author: NRX | Publish date: 2024-10-29 07:54 | Hits: 37
现代农业面临多重挑战，包括全球人口增长、可耕地减少、极端气候频发、病虫害严重、环境污染加剧等。人类食物、动物饲料和工业应用需求的增加要求提高作物产量；消费者对农产品营养健康等个性化需求增加要求提高作…
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Cell Host & Microbe | Alleviating protein-condensation-associated damage at the endoplasmic reticulum enhances plant disease tolerance
Author: NRX | Publish date: 2024-08-08 07:45 | Hits: 39
抗病性（disease resistance）和耐受性（disease tolerance）是宿主固有的两种防御策略（defense strategy）。抗病性通过阻止、限制和杀死病原物的方式保障植…
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Science China Life Sciences | Engineering disease-resistant plants with alternative translation efficiency by switching uORF types through CRISPR
Author: NRX | Publish date: 2024-04-26 11:02 | Hits: 24
抗病育种是防治病虫害、减少农药使用的重要途径。传统的杂交抗病育种策略为粮食安全做出了重要贡献。随着抗病机制的不断解析以及转基因和基因编辑技术的不断发展，基因工程育种成为了抗病育种的另一重要策略。基因…
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Journal of Genetics and Genomics | RNAirport: a deep neural network-based database characterizing representative gene models in plants
Author: NRX | Publish date: 2024-03-20 08:44 | Hits: 13
随着基因组数据的大量释放以及高质量组装的完成，实现编码基因的精准注释十分重要。基因的精准注释需要回答三个基本问题：转录组中RNA有多少种类，其序列信息如何，RNA上的调控元件包含哪些。mRNAs是具…
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Journal of Genetics and Genomics | Translation machinery: the basis of translational control
Author: NRX | Publish date: 2023-08-03 08:19 | Hits: 15
mRNA的翻译过程包括起始、延伸、终止和核糖体再利用。该过程主要由tRNA、核糖体和翻译因子(translation factor, TrF)组成的翻译机器完成。翻译机器能够感知由翻译调节因子传递来…
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Cell Host & Microbe | Global translational induction during NLR-mediated immunity in plants is dynamically regulated by CDC123, an ATP-sensitive protein
Author: NRX | Publish date: 2023-02-17 11:09 | Hits: 20
植物NLR蛋白识别来自病原的effector激活ETI免疫反应，常引起细胞死亡并限制病原菌增殖。ETI反应伴随着大量的转录以及翻译水平的重编程。ETI免疫反应中的转录调控已经有较多文献报道，然而对翻…
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Nature Plants | Plant HEM1 specifies a condensation domain to control immune gene translation
Author: NRX | Publish date: 2023-02-16 08:36 | Hits: 17
植物在生长发育过程中需要严格控制免疫基因的表达，从而使植物的生长和抗性维持平衡。不受控制的表达会直接损害植物的生长发育，我们称之为自免疫autoimmunity，这一现象在人类中同样广泛存在【1,2…
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Cell Discovery | Proximity editing to identify RNAs in phase-separated RNA binding protein condensates
Author: NRX | Publish date: 2021-08-24 08:25 | Hits: 23
2021年8月24日，武汉大学高等研究院、杂交水稻国家重点实验室胥国勇课题组在Cell Discovery在线发表了题为Proximity editing to identify RNAs in p…
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Database | uORFlight: a vehicle toward uORF-mediated translational regulation mechanisms in eukaryotes
Author: NRX | Publish date: 2019-07-26 08:06 | Hits: 32
上游开放阅读框（upstream open reading frame；uORF）广泛存在于真核生物 mRNA中。其作为一种翻译调控元件，精准调控下游有重要生物学功能的主要开放阅读框（major o…
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