Research

Our lab develops innovative technologies to investigate translational control mechanisms, plant disease tolerance, and targeted protein-condensate degradation. Our work is guided by two central biological frameworks: the Bio-triangle relationship, which examines the dynamic interactions among plants, pathogens, and endophytes; and the Trait-triangle relationship, which focuses on balancing immunity, yield, and quality to address the global need for healthier and more productive crops. By uncovering the molecular logic behind these interactions, we aim to engineer crops with improved disease resistance and tolerance—offering sustainable solutions to the challenges facing modern agriculture.

Keywords

Disease symptoms, Disease tolerance, Plant defense, Tissue damage control, Effector-triggered immunity, Necrotrophic disease, Immunopathology, Lipid damage, Rhizoctonia solani; Endoplasmic reticulum, ER-autophagy interplay, Membraneless organelles, Phase separation and transition, Protein condensation; RNA regulatory elements, 5′ leader, uORF, Translational control, Translation efficiency, Translation homeostasis, mRNA annotation, RNA-binding proteins; Rational engineering, Targeted protein-condensate degradation, Microbiome, Ribosome footprinting, TRIBE-RNA editing, Agrobacterium-mediated transformation

主要研究概述

我们实验室致力于开发新技术，以研究翻译调控机制、植物耐病性以及蛋白团聚体靶向降解。我们的研究围绕两个核心生物学框架展开：生物三角关系（Bio-triangle：plant-pathogen-endophyte），即植物、病原体与内生菌之间的动态相互作用；以及性状三角关系（Trait-triangle: defense-yield-quality），旨在在免疫力、产量和品质之间寻求平衡，以应对全球对更多、更健康粮食的需求。通过揭示这些相互作用背后的分子机制，我们的目标是设计出具备更强抗病性和耐病性的作物，从而为现代农业所面临的挑战提供可持续的解决方案。